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The Milk of Human Science
Scientific Studies
Published References

SMBI has compiled numerous published references pertaining to scientific studies conducted utilizing SMBI and other milk products. To follow is a listing of those references:

Golay, A., Ferrara, J.M., Felber, J.P. and Schneider, H. (1990) Cholesterol-Lowering Effect of Skim Milk from Immunized Cows in Hypercholesterolemic Patients. American Journal of Clinical Nutrition 52:6, 1014-1019.

Filler, S.J., Gregory, R.L., Michalek, S.M., Katz, J., and Mcghee, J.R. (1991) Effect of Immune Bovine Milk on Streptococcus-Mutans in Human Dental Plaque. Archives of Oral Biology 36:1, 41-47.

Ormrod, D.J. and Miller, T.E. (1991) The Anti-Inflammatory Activity of a Low Molecular Weight Component Derived from the Milk of Hyperimmunized Cows. Agents and Actions 32:3-4, 160-166.

Murosaki, S., Yoshikai, Y., Kubo, C., Ishida, A., Matsuzaki, G., Sato, T., Endo, K. and Nomoto, K. (1991) Influence of Intake of Skim Milk from Cows Immunized with Intestinal Bacterial Antigens on Onset of Renal Disease in (NZB X NZW)F1 Mice Fed Ad Libitum or Restricted in Energy Intake. Journal of Nutrition 121:11, 1860-1868.

Owens, W.E., Nickerson, S.C. and Washburn, P.J. (1992) Effect of a Milk-Derived Factor on the Inflammatory Response to Staphylococcus aureus Intramammary Infection. Veterinary Immunology and Immunopathology 30:2-3, 233-246.

Flanigan, T., Marshall, R., Redman, D., Kaetzel, C. and Ungar, B. (1991) In Vitro Screening of Therapeutic Agents Against Cryptosporidium - Hyperimmune Cow Colostrum Is Highly Inhibitory. Journal of Protozoology 38:6, S225-S227.

Ishida, A., Yoshikai, Y., Murosaki, S., Kubo, C., Hidaka, Y. and Nomoto, K. (1992) Consumption of Milk from Cows Immunized with Intestinal Bacteria Influences Age-Related Changes in Immune Competence in Mice. Journal of Nutrition 122:9, 1875-1883.

Tacket, C.O., Binion, S.B., Bostwick, E., Losonsky, G., Roy, M.J. and Edelman, R. (1992) Efficacy of Bovine Milk Immunoglobulin Concentrate in Preventing Illness After Shigella-flexneri Challenge. (1992) American Journal of Tropical Medicine and Hygiene 47:3, 276-283.

Ishida, A., Yoshikai, Y., Murosaki, S., Hidaka, Y. and Nomoto, K. (1992) Administration of Milk from Cows Immunized with Intestinal Bacteria Protects Mice from Radiation- Induced Lethality. Biotherapy 5:3, 215-225.

Plettenberg, A., Stoehr, A., Stellbrink, H.J., Albrecht, H., and Meigel, W. (1993) A Preparation from Bovine Colostrum in the Treatment of HIV-Positive Patients with Chronic Diarrhea. Clinical Investigator 71:1, 42-45.

Husu, J. Syvaoja, E.L., Aholaluttila, H., Kalsta, H., Sivela, S. and Kosunen, T.U. (1993) Production of Hyperimmune Bovine Colostrum Against Campylobacter jejuni. Journal of Applied Bacteriology 74:5, 564-569.

Sharpe, S.J., Gamble, G.D. and Sharpe, D.N. (1994) Cholesterol-Lowering and Blood Pressure Effects of Immune Milk. American Journal of Clinical Nutrition 59:4, 929-934.

Goldblum, R.M. and Goldman, A.S. (1994) Immunological Components of Milk: Formation and Function. Handbook of Mucosal Immunology 643-652.

Kelly C.P., Pothoulakis C., Vavva F., Castagliuolo I., Bostwick E.F., Okeane J.C., Keates S. and Lamont J.T. (1996) Anti-Clostridium Difficile Bovine Immunoglobulin Concentrate Inhibits Cytotoxicity and Enterotoxicity of C-Difficile Toxins. Antimicrobial Agents & Chemotherapy 40:2, 373-379.

Dial E.J., Romero J.J. and Lichtenberger L.M. (1995) Gastroprotection by Dairy Foods Against Stress-Induced Ulcerogenesis in Rats. Digestive Diseases & Sciences 40:11, 2295-2299.

Harmsen, M.C., Swart, P.J., Debethune, M.P., Pauwels R., Declercq E., The, T.H. and Meijer, D.K.F. (1995) Antiviral Effects of Plasma and Milk Proteins - Lactoferrin Shows Potent Activity Against Both Human Immunodeficiency Virus and Human Cytomegalovirus Replication In Vitro. Journal of Infectious Diseases 172:2, 380-388.

Korhonen, H., Syvaoja, E.L., Aholaluttila, H., Sivela, S., Kopola, S. and Husu, J. (1995) Bactericidal Effect of Bovine Normal and Immune Serum, Colostrum and Milk Against Helicobacter pylori. Journal of Applied Bacteriology 78:6, 655-662.

Goldman, A.S., Thorpe, L.W., Goldblum, R. M. and Hanson, L.A. (1986) Anti-inflammatory Properties of Human Milk. Acta Paediatrica Scandinavica 75, 689-695.

Tockman, M.S., Khoury, M.J. and Cohen, B.H. (1986) Milk Drinking and Possible Protection of the Respiratory Epithelium. Journal of Chronic Disease 39:3, 207-209.

Ebina, T., Sato, A., Umezu, K., Ishida, N., Ohyama, S., Oizumi, A., Aikawa, K., Katagiri, S., Katsushim, N., Imai, A., Kitaoka, K., Suzuki H, Konno, T. (1985) Prevention of Rotavirus Infection by Oral Administration of Cow Colostrum Containing Anti-human Rotavirus Antibody. Medical Microbiology and Immunology 174, 177-185.

Tacket, C.O., Losonsky, G., Link, H., Hoang, Y., Guesry, P., Hilpert, H. and Levine, M. (1988) Protection by Milk Immunoglobulin Concentrate Against Oral Challenge With Enterotoxigenic Escherichia coli. The New England Journal of Medicine 318:19, 1240-1243.

Michalek, S.M., Gregory, R.L., Harmon, C.C., Katz, J., Richardson, G.J., Hilton, T., Filler, S.J. and McGhee J.R (1987) Protection of Gnotobiotic Rats Against Dental Caries by Passive Immunization With Bovine Milk Antibodies to Streptococcus mutans. Infection and Immunity 55:10, 2341-2347.

Losnedahl, K.J., Wang, H., Aslam, M., Zou, S. and Hurley, W.L. (1996) Antimicrobial Factors in Milk. Illinois Dairy Report 1996.

Takahashi N., Eisenhuth, G., Lee, I. and Schachtele, C. (1992) Nonspecific Antibacterial Factors in Milk from Cows Immunized with Human Oral Bacterial Pathogens. Journal of Dairy Science. 75, 1810-1820.

Loimaranta, V., Tenovuo, J., Virtanen, S., Marnila, P., Syvaoja, E.L., Tupasela, T. and Korhonen, H. (1997) Generation of Bovine Immune Colostrum Against Streptococcus Mutans and Streptococcus Sobrinus and Its Effect on Glucose Uptake and Extracellular Polysaccharide Formation by Mutans Streptococci. Vaccine 15:11, 1261-1268.

Freedman, D.J., Tacket, C.O., Delehanty, A., Maneval, D.R., Nataro, J. and Crabb, J.H. (1998) Milk Immunoglobulin with Specific Activity Against Purified Colonization Factor Antigens Can Protect Against Oral Challenge with Enterotoxigenic Escherichia Coli. Journal of Infectious Diseases 177:3, 662-667.

Beck., L.R. and Fuhrer, J.P. (1994) Milk Lymphocyte Anti-Adhesion Factor, and Its Role as an Anti-Microbial. Indigenous Antimicrobial Agents of Milk - Recent Developments. Uppsala: Int. Dairy Fed., 62-72.

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